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KMID : 1123920100240010118
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 1 p.118 ~ p.123
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Anti-adipogencic Effect of Piper Nigrum Linne
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Jeong Hong-Suk
Jung Ji-Chun
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Abstract
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Piper nigrum Linne has been used spice as well as herbal medicine in worldwide and has function of anti-oxidant, anti-inflammation, anti-cancer, bioavailability of drugs and etc. In this study, anti-adipogenic activity of Piper nigrum Linne extract and its constituent piperine were investigated in 3T3-L1 differentiation. Adipogenic effects and lipid accumulation in 3T3-L1 was measured by RT-PCR and Oil Red O staining assays respectively in stimulation of Piper nigrum Linne extract and piperine. Piper nigrum Linne and piperine reduced lipid accumulation in 3T3-L1 differentiation and expression of genes associated with adipogenesis such as PPAR, adipsin, SERBP-1c and LPL. All of taken, anti-adipogenic mechanism of Piper nigrum Linne and piperine were related with regulation of SREBP-1c and PPAR expression.
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KEYWORD
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Piper nigrum Linne, piperine, adipogenesis, 3T3-L1 differentiation, PPARγ , SREPB-1c
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